It’s important to be aware that certain medications can interact with each other, potentially leading to serious side effects. Always inform your doctor or pharmacist if you are currently using or have recently used any other medications. These may include monoamine oxidase inhibitors (MAOIs) such as phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine (used for depression), or selegiline (used for Parkinson’s disease), which should not be taken with Amitriptyline tablets. Other medications to watch out for include adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine (found in some cough or cold medicines and anesthetics), as well as high blood pressure medications like calcium-channel blockers (e.g., diltiazem, verapamil), guanethidine, betanidine, clonidine, reserpine, and methyldopa. Anticholinergic drugs used for Parkinson’s disease and gastrointestinal disorders (e.g., atropine, hyoscyamine), thioridazine (for schizophrenia), pain relievers like nefopam, tramadol, and morphine, and buprenorphine (for severe pain or opioid addiction) can also interact with amitriptyline, potentially causing symptoms such as muscle contractions, agitation, hallucinations, coma, excessive sweating, tremors, heightened reflexes, muscle tension, or elevated body temperature. Be cautious with antifungal medications (e.g., fluconazole, terbinafine, ketoconazole, itraconazole), sedatives (e.g., barbiturates), antidepressants (e.g., SSRIs like fluoxetine, paroxetine, fluvoxamine, duloxetine, bupropion), certain heart medications (e.g., beta blockers, antiarrhythmics), cimetidine (for stomach ulcers), and methylphenidate (for ADHD). If you experience any unusual symptoms, contact your healthcare provider promptly. For a full list refer to the Patient Information Leaflet.

The side effects of Amitriptyline have been reported at various frequencies. Frequently reported side effects (experienced by more than 1 in 10 people) include drowsiness or sleepiness, trembling of hands or other body parts, dizziness, headaches, orthostatic hypotension (dizziness upon standing due to low blood pressure), irregular or rapid heartbeat, dry mouth, constipation, nausea, excessive sweating, weight gain, slurred speech, aggression, and nasal congestion. Common side effects (affecting up to 1 in 10 people) include confusion, sexual disturbances such as decreased libido or erectile dysfunction, attention disturbances, changes in taste perception, numbness or tingling in the limbs, impaired coordination, dilated pupils, heart block, fatigue, low blood sodium levels, agitation, urinary problems, and increased thirst. Less common side effects (experienced by up to 1 in 100 people) include feelings of excitement, anxiety, insomnia, and nightmares. For a full list refer to the Patient Information Leaflet.